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Combined petrosal approach for resection of a large left petroclival meningioma. Francesco Paglia, Lorenzo Giammattei, Paolo di Russo and Sebastien Froelich

Combined petrosal approach for resection of a large left petroclival meningioma. Francesco Paglia, Lorenzo Giammattei, Paolo di Russo and Sebastien Froelich

  Petroclival meningiomas represent the most complex lesions in skull base surgery, being closely related to critical neurovascular structures. The combined petrosal approach allows a wide exposure of the petroclival region and provides multiple angles of attack, limiting brain retraction. The authors present the case of a 54-year-old man with a large left petroclival meningioma […]

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In vivo efficacy assessment of the CDK4/6 inhibitor palbociclib and the PLK1 inhibitor volasertib in human chordoma xenografts

In vivo efficacy assessment of the CDK4/6 inhibitor palbociclib and the PLK1 inhibitor volasertib in human chordoma xenografts

  Abstract Background: Management of advanced chordomas remains delicate considering their insensitivity to chemotherapy. Homozygous deletion of the regulatory gene CDKN2A has been described as the most frequent genetic alteration in chordomas and may be considered as a potential theranostic marker. Here, we evaluated the tumor efficacy of the CDK4/6 inhibitor palbociclib, as well as […]

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Intraoperative Mapping of Cognitive Networks : Which Tasks for Which Locations. De Emmanuel Mandonnet et Guillaume Herbet

Intraoperative Mapping of Cognitive Networks : Which Tasks for Which Locations. De Emmanuel Mandonnet et Guillaume Herbet

  This book aims to give the state-of-the-art of intraoperative brain function mapping for resection of brain tumors in awake conditions, and to become a reference for acquiring the fundamental expertise necessary to select the right intraoperative task at the right time of the surgery. The chapters, all focused on a specific brain function, are […]

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Focal Cortical Dysplasias, New advances for curing epilepsy, de Francine Chassoux et André Palmini

Focal Cortical Dysplasias, New advances for curing epilepsy, de Francine Chassoux et André Palmini

  L’ouvrage marque le 50ème anniversaire de la première description de la dysplasie de Taylor, qui a révolutionné le monde de l’épilepsie et retrace l’histoire de l’évolution des concepts dans le monde de la recherche clinique et fondamentale. Les plus grands experts internationaux en épileptologie, neurophysiologie, neuropathologie, génétique, imagerie et neurochirurgie, ont conçu cet ouvrage […]