Abstract Background: Management of advanced chordomas remains delicate considering their insensitivity to chemotherapy. Homozygous deletion of the regulatory gene CDKN2A has been described as the most frequent genetic alteration in chordomas and may be considered as a potential theranostic marker. Here, we evaluated the tumor efficacy of the CDK4/6 inhibitor palbociclib, as well as the PLK1 inhibitor volasertib, in three chordoma patient-derived xenograft (PDX) models to validate and identify novel therapeutic approaches. Methods: From our chordoma xenograft panel, we selected three models, two of them harboring a homozygous deletion of CDKN2A/2B genes, and the last one a PBRM1 pathogenic variant (as control). For each model, we tested the palbociclib and volasertib drugs with pharmacodynamic studies together with RT-PCR and RNAseq analyses. Results: For palbociclib, we observed a significant tumor response for one of two models harboring the deletion of CDKN2A/2B (p = 0.02), and no significant tumor response in the PBRM1-mutated PDX; for volasertib, we did not observe any response in the three tested models. RT-PCR and RNAseq analyses showed a correlation between cell cycle markers and responses to palbociclib; finally, RNAseq analyses showed a natural enrichment of the oxidative phosphorylation genes (OxPhos) in the palbociclib-resistant PDX (p = […]

  This book aims to give the state-of-the-art of intraoperative brain function mapping for resection of brain tumors in awake conditions, and to become a reference for acquiring the fundamental expertise necessary to select the right intraoperative task at the right time of the surgery. The chapters, all focused on a specific brain function, are divided in 4 parts: sensori-motor and visuo-spatial functions, language functions, higher-order functions, and prospects. Each chapter follows the same outline, including a brief review of the current knowledge about the networks sustaining the function in healthy subjects, the description of the intraoperative tasks designed to monitor the function, a review of the literature describing the deficits in that function after surgery, and a critical appraisal of the benefit provided by intraoperative mapping of that function. Comprehensive state-of the-art of intraoperative brain functions testing Common approach for all chapters Each chapter is written in tandem by a neurosurgeon and a neuropsychologist About the editors Emmanuel Mandonnet is currently full Professor of neurosurgery at Lariboisière hospital, University of Paris. After achieving a PhD in physics in 2000, he turned towards medical school and then residency in neurosurgery. His clinical and research activities focus on brain tumors, and […]

Endoscope-assisted far-lateral transcondylar approach for craniocervical junction chordomas: a retrospective case series and cadaveric dissection

Research Use of high dose cyproterone acetate and risk of intracranial meningioma in women: cohort study BMJ 2021

Specialties / Course calendar  

SKULL BASE SATURDAY : SBN Sociedade Brasileira de Neurocirurgia

  Neurochirurgie guidée par l’image – Presentation du Pr Emmanuel Mandonnet au Collège de France – 27 mai 2014       Au cours de cet exposé, nous analyserons comment différents modèles biomathématiques de l’évolution des gliomes intracérébraux et de leur interaction avec le fonctionnement cérébral peuvent – ou pourront dans un futur proche – aider le neurochirurgien aux différentes étapes de la prise en charge du patient. En pré-opératoire, le modèle de croissance tumorale de prolifération-diffusion, alimenté par les IRM consécutives d’un patient, permet de déterminer la cinétique de croissance individuelle, élément fondamental dans la prise de décision opératoire. D’autre part, l’atlas de résécabilité fonctionnelle – construit à partir des résidus postopératoires de séries de patients opérés dans des centres de références et ayant pour but de pouvoir estimer objectivement si la tumeur d’un patient est opérable ou non – fournit un outil privilégié pour homogénéiser les stratégies de prise en charge entre différentes institutions. Pendant l’opération, le chirurgien s’aide de la neuronavigation comme d’un GPS intra-cérébral. Mais le « brain shift », généré par l’effondrement du cerveau au fur et à mesure de l’exérèse, limite considérablement la précision de cet outil (jusqu’à 1 cm de décalage). Des algorithmes de correction en temps réel, prenant en […]

Towards Individualised and Optimalised Positioning of Non-Ventilated COVID-19 Patients: Putting the Affected Parts of the Lung(s) on Top?  

Vertebrobasilar Artery Encasement by Skull Base Chordomas: Surgical Outcome and Management Strategies – Operative Neurosurgery April 2020

Impact of COVID-19 Pandemic on Subarachnoid Hemorrhage – Journal of Neurosurgical Sciences 2020 April  

From the Occipital Condyle to the Sphenoid Sinus: Extradural Extension of the Far Lateral Transcondylar Approach with Endoscopic Assistance   ValentinaTardivo – MoujahedLabidi – ThibaultPasseri –  Anne LaureBernat –  FrancescoZenga –  EduardVoormolen – NicolasPenet –  SebastienFroelich.

Nouvelle publication : Anterolateral Approach with Endoscopic Assistance for Resection of a Craniovertebral Junction Chordoma  

Spontaneous regression of meningiomas after interruption of nomegestrol acetate: a series of three patients.    

Combined hormonal influence of cyproterone acetate and nomegestrol acetate on meningioma: a case report.  

Regression of Giant Olfactory Groove Meningioma and Complete Visual Acuity Recovery after Discontinuation of Cyproterone Acetate. Bernat AL, Bonnin S, Labidi M, Aldahak N, Bresson D, Bouazza S, Froelich S

2018 Sep;117:208-220. The Chopsticks Technique for Endoscopic Endonasal Surgery-Improving Surgical Efficiency and Reducing the Surgical Footprint. Labidi M, Watanabe K, Hanakita S, Park HH, Bouazza S, Bernat AL, Froelich S.

The Posterior Transpetrosal Approach in a Case of Large Retrochiasmatic Craniopharyngioma: Operative Video and Technical Nuances. Labidi M, Watanabe K, Loit MP, Hanakita S, Froelich S.

Skull base neurosurgery course Trans-petrosal approaches: anterior and posterior petrosal, combined approach Orbito-zygomatic approach, clinoidectomy and cavernous sinus Live surgery  

Course Masterclass 17 & 18 novembre 2017

Course Masterclass 27 & 28 novembre 2017