Archives d'étiquettes : MEDICAL EDUCATION

New publication

Publié par La direction

4 septembre 2019

Nouvel Ouvrage : Le service de Neurochirurgie Lariboisiere participe aux recommendations internationales sur la chirurgie de la base du crâne endoscopique

Cours

Publié par La direction

5 avril 2019

7th Neurosurgical Skull Base Masterclass

New publication

Publié par La direction

30 mars 2019

Spontaneous regression of meningiomas after interruption of nomegestrol acetate: a series of three patients.

Spontaneous regression of meningiomas after interruption of nomegestrol acetate: a series of three patients.

New publication

Publié par La direction

30 mars 2019

Combined hormonal influence of cyproterone acetate and nomegestrol acetate on meningioma: a case report.

Combined hormonal influence of cyproterone acetate and nomegestrol acetate on meningioma: a case report.

New publication

Publié par La direction

7 octobre 2018

New Publication from our group : Endoscopic Endonasal Approach to the Anteromedial Temporal Fossa and Mobilization of the Lateral Wall of the Cavernous Sinus Through the Inferior Orbital Fissure and V1-V2 Corridor

Endoscopic Endonasal Approach to the Anteromedial Temporal Fossa and Mobilization of the Lateral Wall of the Cavernous Sinus Through the Inferior Orbital Fissure and V1-V2 Corridor: An Anatomic Study and Clinical Considerations Hanakita S, Chang WC, Watanabe K, Ronconi D, Labidi M, Park HH, Oyama K, Bernat AL, Froelich S. V1V2

Publié par La direction

15 avril 2018

New publication from our group: The Posterior Transpetrosal Approach for Large Retrochiasmatic Craniopharyngioma

The Posterior Transpetrosal Approach in a Case of Large Retrochiasmatic Craniopharyngioma: Operative Video and Technical Nuances. Labidi M, Watanabe K, Loit MP, Hanakita S, Froelich S.

Publié par admin

6 novembre 2017

First Neurosurgical Skull Base Courses

Course Masterclass 17 & 18 novembre 2017

Cours

Publié par Le Personnel

27 octobre 2017

4th Skull Base MasterClass Medtronic

Course Masterclass 27 & 28 novembre 2017

Cours

Publié par admin

12 septembre 2016

Cours avancés « Skull Base 360 »

MICROSCOPIC and ENDOSCOPIC – APPROACHES to the SKULL BASE TRAINING on ANATOMICAL SPECIMEN [pdf-embedder url= »https://www.neurochirurgie-lariboisiere.com/wp-content/uploads/2016SB1050823-2.pdf »]

Latest News on Your Doctor's Blog

Chargemente en cours de…

Cours avancés « Skull Base 360 »

12septembre
2016

Cours avancés « Skull Base 360 »

MICROSCOPIC and ENDOSCOPIC – APPROACHES to the SKULL BASE TRAINING on ANATOMICAL SPECIMEN [pdf-embedder url= »https://www.neurochirurgie-lariboisiere.com/wp-content/uploads/2016SB1050823-2.pdf »]

Publié par admin

Keller Lectureship

1avril
2017

Keller Lectureship

Mayfield & Foundation UC Department of Neurosurgery cordially invite you to the 6th annual Keller Lectureship in surgical neuroanatomy & research. [pdf-embedder url= »https://www.neurochirurgie-lariboisiere.com/wp-content/uploads/eveKellerLect2017.pdf » title= »_eveKellerLect2017″]

Publié par admin

30août
2017

100 Years Otorhinolaryngology

Cochlear congratulates UniversityHospital Zürich on 100 years ORL. Working together in partnership is how breakthroughs are achieved. USZ has helped countless people directly and indirectly through their commitment to always furthering ideas in research and surgery. Cochlear is proud to celebrate this achievement and looks forward to furthering research together in partnership for many years to come. [pdf-embedder url= »https://www.neurochirurgie-lariboisiere.com/wp-content/uploads/Program-100-years-ENT-departement.pdf » title= »Program 100 years ENT departement »]

Publié par admin

4th Skull Base MasterClass Medtronic

27octobre
2017

4th Skull Base MasterClass Medtronic

Course Masterclass 27 & 28 novembre 2017

Publié par Le Personnel

First Neurosurgical Skull Base Courses

6novembre
2017

First Neurosurgical Skull Base Courses

Course Masterclass 17 & 18 novembre 2017

Publié par admin

New Publication from Our Group: Combined Nasoseptal and Inferior Turbinate Flap for Reconstruction of Large Skull Base Defect After Expanded Endonasal Approach

7avril
2018

New Publication from Our Group: Combined Nasoseptal and Inferior Turbinate Flap for Reconstruction of Large Skull Base Defect After Expanded Endonasal Approach

Combined Nasoseptal and Inferior Turbinate Flap for Reconstruction of Large Skull Base Defect After Expanded Endonasal Approach: Operative technique. Julien Boetto, MD Moujahed Labidi, MD Kentaro Watanabe, MDShunya Hanakita, MD Schahrazed Bouazza, MD Thibault Passeri, MDAnne-Laure Bernat, MD, Sebastien Froelich, MD

Publié par La direction

Lariboisière Skull Base Master Class, Avril 13-14

7avril
2018

Lariboisière Skull Base Master Class, Avril 13-14

Cours de base du crâne dans notre laboratoire de Neurochirurgie expériementale: Voies transpetreuses, abord FTOZ

Publié par La direction

Second Lariboisiere Skull Base – Cusa Clarity Masterclass – 12 et 13 avril 2017

15avril
2018

Second Lariboisiere Skull Base – Cusa Clarity Masterclass – 12 et 13 avril 2017

Skull base neurosurgery course Trans-petrosal approaches: anterior and posterior petrosal, combined approach Orbito-zygomatic approach, clinoidectomy and cavernous sinus Live surgery

Publié par La direction

New publication from our group: The Posterior Transpetrosal Approach for Large Retrochiasmatic Craniopharyngioma

15avril
2018

New publication from our group: The Posterior Transpetrosal Approach for Large Retrochiasmatic Craniopharyngioma

The Posterior Transpetrosal Approach in a Case of Large Retrochiasmatic Craniopharyngioma: Operative Video and Technical Nuances. Labidi M, Watanabe K, Loit MP, Hanakita S, Froelich S.

Publié par La direction

New Publication from our group : Endoscopic Endonasal Approach to the Anteromedial Temporal Fossa and Mobilization of the Lateral Wall of the Cavernous Sinus Through the Inferior Orbital Fissure and V1-V2 Corridor

7octobre
2018

New Publication from our group : Endoscopic Endonasal Approach to the Anteromedial Temporal Fossa and Mobilization of the Lateral Wall of the Cavernous Sinus Through the Inferior Orbital Fissure and V1-V2 Corridor

Endoscopic Endonasal Approach to the Anteromedial Temporal Fossa and Mobilization of the Lateral Wall of the Cavernous Sinus Through the Inferior Orbital Fissure and V1-V2 Corridor: An Anatomic Study and Clinical Considerations Hanakita S, Chang WC, Watanabe K, Ronconi D, Labidi M, Park HH, Oyama K, Bernat AL, Froelich S. V1V2

Publié par La direction

Resection of an Optic Canal Meningioma through a Contralateral Subfrontal Approach with Endoscopic Assistance: A 2D Operative Video. Labidi M, Watanabe K, Bernat AL, Hanakita S, Froelich S

7octobre
2018

Resection of an Optic Canal Meningioma through a Contralateral Subfrontal Approach with Endoscopic Assistance: A 2D Operative Video. Labidi M, Watanabe K, Bernat AL, Hanakita S, Froelich S

Resection of an Optic Canal Meningioma through a Contralateral Subfrontal Approach with Endoscopic Assistance: A 2D Operative Video. Labidi M, Watanabe K, Bernat AL, Hanakita S, Froelich S

Publié par La direction

World Neurosurgery Sept 2018. The Chopsticks Technique for Endoscopic Endonasal Surgery-Improving Surgical Efficiency and Reducing the Surgical Footprint.

8octobre
2018

World Neurosurgery Sept 2018. The Chopsticks Technique for Endoscopic Endonasal Surgery-Improving Surgical Efficiency and Reducing the Surgical Footprint.

2018 Sep;117:208-220. The Chopsticks Technique for Endoscopic Endonasal Surgery-Improving Surgical Efficiency and Reducing the Surgical Footprint. Labidi M, Watanabe K, Hanakita S, Park HH, Bouazza S, Bernat AL, Froelich S.

Publié par La direction

Regression of Giant Olfactory Groove Meningioma and Complete Visual Acuity Recovery after Discontinuation of Cyproterone Acetate.

8octobre
2018

Regression of Giant Olfactory Groove Meningioma and Complete Visual Acuity Recovery after Discontinuation of Cyproterone Acetate.

Regression of Giant Olfactory Groove Meningioma and Complete Visual Acuity Recovery after Discontinuation of Cyproterone Acetate. Bernat AL, Bonnin S, Labidi M, Aldahak N, Bresson D, Bouazza S, Froelich S

Publié par La direction

Le chordome : Une tumeur rare de la base du crâne. Magazine de la santé 7 décembre 2018

23décembre
2018

Le chordome : Une tumeur rare de la base du crâne. Magazine de la santé 7 décembre 2018

Magazine de la santé. Reportage sur les chordomes, une tumeur rare de la base du crâne. Emission du 7 décembre 2018

Publié par La direction

Hotspots of small strokes in glioma surgery: an overlooked risk? Acta Neurochir (Wien). 2018 Nov 10

28décembre
2018

Hotspots of small strokes in glioma surgery: an overlooked risk? Acta Neurochir (Wien). 2018 Nov 10

Loit MP, Rheault F, Gayat E, Poisson I, Froelich S, Zhi N, Velut S, Mandonnet E Acta Neurochir (Wien). 2018 Nov 10.

Publié par La direction

Combined hormonal influence of cyproterone acetate and nomegestrol acetate on meningioma: a case report.

30mars
2019

Combined hormonal influence of cyproterone acetate and nomegestrol acetate on meningioma: a case report.

Combined hormonal influence of cyproterone acetate and nomegestrol acetate on meningioma: a case report.

Publié par La direction

Spontaneous regression of meningiomas after interruption of nomegestrol acetate: a series of three patients.

30mars
2019

Spontaneous regression of meningiomas after interruption of nomegestrol acetate: a series of three patients.

Spontaneous regression of meningiomas after interruption of nomegestrol acetate: a series of three patients.

Publié par La direction

7th Neurosurgical Skull Base Masterclass

5avril
2019

7th Neurosurgical Skull Base Masterclass

Publié par La direction

How I do it : Combined petrosectomy

27août
2019

How I do it : Combined petrosectomy

Publié par La direction

Nouvel Ouvrage : Le service de Neurochirurgie Lariboisiere participe aux recommendations internationales sur la chirurgie de la base du crâne endoscopique

4septembre
2019

Nouvel Ouvrage : Le service de Neurochirurgie Lariboisiere participe aux recommendations internationales sur la chirurgie de la base du crâne endoscopique

Publié par La direction

1ère Journée d’Information sur le Chordome

13octobre
2019

1ère Journée d’Information sur le Chordome

Publié par La direction

Nouveau scanner intra-opératoire – AERO Brainlab – Pour la chirurgie crânienne et rachidienne

2novembre
2019

Nouveau scanner intra-opératoire – AERO Brainlab – Pour la chirurgie crânienne et rachidienne

Le service de Neurochirurgie dispose depuis Novembre 2019 d’un scanner intra-opératoire. Cette technologie nouvelle au bloc opératoire permettra Pour la chirurgie intra-crânienne et de la base du crâne : de réduire au maximum le traumatisme chirurgical en utilisant des voies d’abord mini-invasives ciblées, d’améliorer la précision du geste chirurgical, de biopsier des lésions profondes de manière plus sûr, sous contrôle de l’image, d’améliorée la qualité de l’exérèse des tumeurs cérébrales et de la base du crâne, de rassurer de l’exclusion complète de certaines lesions vasculaires complexes, De controler la qualité d’une résection et l’absence de complication en post-opératoire immédiat avant la sortie de salle d’opération. Pour la chirurgie rachidienne : d’utiliser des voies d’accès ciblées, mini-invasives, moins traumatisantes, de réaliser des vissage (Arthrodèse – Ostéosynthèse) par voie per-cutanée, de rendre le geste chirurgical plus sûr.

Publié par La direction

Endoscopic endonasal approach to the mesial temporal lobe: anatomical study and clinical considerations for a selective amygdalohippocampectomy – Acta Neurochirurgica December 2019

3décembre
2019

Endoscopic endonasal approach to the mesial temporal lobe: anatomical study and clinical considerations for a selective amygdalohippocampectomy – Acta Neurochirurgica December 2019

Endoscopic endonasal approach to the mesial temporal lobe: anatomical study and clinical considerations for a selective amygdalohippocampectomy

Publié par La direction

Anterolateral Approach with Endoscopic Assistance for Resection of a Craniovertebral Junction Chordoma

5janvier
2020

Anterolateral Approach with Endoscopic Assistance for Resection of a Craniovertebral Junction Chordoma

Nouvelle publication : Anterolateral Approach with Endoscopic Assistance for Resection of a Craniovertebral Junction Chordoma

Publié par La direction

From the Occipital Condyle to the Sphenoid Sinus: Extradural Extension of the Far Lateral Transcondylar Approach with Endoscopic Assistance

5janvier
2020

From the Occipital Condyle to the Sphenoid Sinus: Extradural Extension of the Far Lateral Transcondylar Approach with Endoscopic Assistance

From the Occipital Condyle to the Sphenoid Sinus: Extradural Extension of the Far Lateral Transcondylar Approach with Endoscopic Assistance ValentinaTardivo – MoujahedLabidi – ThibaultPasseri – Anne LaureBernat – FrancescoZenga – EduardVoormolen – NicolasPenet – SebastienFroelich.

Publié par La direction

Surmonter l’obstacle de la langue dans la chirurgie des tumeurs cérébrales en condition éveillée chez les migrants

5janvier
2020

Surmonter l’obstacle de la langue dans la chirurgie des tumeurs cérébrales en condition éveillée chez les migrants

Surmonter l’obstacle de la langue dans la chirurgie des tumeurs cérébrales en condition éveillée chez les migrants Sylvie Aubrun Isabelle Poisson Marion Barberis Chadia Draou Mariane Toure Catarina Madadaki Sébastien Froelich Etienne Gayat Emmanuel Mandonnet

Publié par admin

Hybrid Antero-Lateral Transcondylar Approach to the Clivus: A Laboratory Investigation and Case Illustration – Acta Neurochirurgica (2020)

3mai
2020

Hybrid Antero-Lateral Transcondylar Approach to the Clivus: A Laboratory Investigation and Case Illustration – Acta Neurochirurgica (2020)

Hybrid Antero-Lateral Transcondylar Approach to the Clivus: A Laboratory Investigation and Case Illustration – Acta Neurochirurgica (2020)

Publié par La direction

Impact of COVID-19 Pandemic on Subarachnoid Hemorrhage – Journal of Neurosurgical Sciences 2020 April

3mai
2020

Impact of COVID-19 Pandemic on Subarachnoid Hemorrhage – Journal of Neurosurgical Sciences 2020 April

Impact of COVID-19 Pandemic on Subarachnoid Hemorrhage – Journal of Neurosurgical Sciences 2020 April

Publié par La direction

Vertebrobasilar Artery Encasement by Skull Base Chordomas: Surgical Outcome and Management Strategies – Operative Neurosurgery April 2020

3mai
2020

Vertebrobasilar Artery Encasement by Skull Base Chordomas: Surgical Outcome and Management Strategies – Operative Neurosurgery April 2020

Vertebrobasilar Artery Encasement by Skull Base Chordomas: Surgical Outcome and Management Strategies – Operative Neurosurgery April 2020

Publié par La direction

Petroclival meningiomas: the risk of post-operative cranial nerve deficits among different surgical approaches—a systematic review and meta-analysis, Acta Neurochirurgica (2020)

24mai
2020

Petroclival meningiomas: the risk of post-operative cranial nerve deficits among different surgical approaches—a systematic review and meta-analysis, Acta Neurochirurgica (2020)

Petroclival meningiomas: the risk of post-operative cranial nerve deficits among different surgical approaches—a systematic review and meta-analysis, Acta Neurochirurgica (2020)

Publié par La direction

The Orbitopterygoid Corridor as a Deep Keyhole for Endoscopic Access to the Paranasal Sinuses and Clivus

5juillet
2020

The Orbitopterygoid Corridor as a Deep Keyhole for Endoscopic Access to the Paranasal Sinuses and Clivus

The Orbitopterygoid Corridor as a Deep Keyhole for Endoscopic Access to the Paranasal Sinuses and Clivus

Publié par La direction

OUR CONTRIBUTION AGAINST COVID : Towards Individualised and Optimalised Positioning of Non-Ventilated COVID-19 Patients: Putting the Affected Parts of the Lung(s) on Top?

5juillet
2020

OUR CONTRIBUTION AGAINST COVID : Towards Individualised and Optimalised Positioning of Non-Ventilated COVID-19 Patients: Putting the Affected Parts of the Lung(s) on Top?

Towards Individualised and Optimalised Positioning of Non-Ventilated COVID-19 Patients: Putting the Affected Parts of the Lung(s) on Top?

Publié par La direction

Neurochirurgie guidée par l’image – Presentation du Pr Emmanuel Mandonnet au collège de France

12juillet
2020

Neurochirurgie guidée par l’image – Presentation du Pr Emmanuel Mandonnet au collège de France

Neurochirurgie guidée par l’image – Presentation du Pr Emmanuel Mandonnet au Collège de France – 27 mai 2014 Au cours de cet exposé, nous analyserons comment différents modèles biomathématiques de l’évolution des gliomes intracérébraux et de leur interaction avec le fonctionnement cérébral peuvent – ou pourront dans un futur proche – aider le neurochirurgien aux différentes étapes de la prise en charge du patient. En pré-opératoire, le modèle de croissance tumorale de prolifération-diffusion, alimenté par les IRM consécutives d’un patient, permet de déterminer la cinétique de croissance individuelle, élément fondamental dans la prise de décision opératoire. D’autre part, l’atlas de résécabilité fonctionnelle – construit à partir des résidus postopératoires de séries de patients opérés dans des centres de références et ayant pour but de pouvoir estimer objectivement si la tumeur d’un patient est opérable ou non – fournit un outil privilégié pour homogénéiser les stratégies de prise en charge entre différentes institutions. Pendant l’opération, le chirurgien s’aide de la neuronavigation comme d’un GPS intra-cérébral. Mais le « brain shift », généré par l’effondrement du cerveau au fur et à mesure de l’exérèse, limite considérablement la précision de cet outil (jusqu’à 1 cm de décalage). Des algorithmes de correction en temps réel, prenant en […]

Publié par La direction

WEBINAR SKULL BASE SATURDAY

12juillet
2020

WEBINAR SKULL BASE SATURDAY

SKULL BASE SATURDAY – INTERNATIONAL ONLINE WEBINAR

Publié par La direction

Surgical management for large vestibular schwannomas: a systematic review, meta-analysis, and consensus statement on behalf of the EANS skull base section

12septembre
2020

Surgical management for large vestibular schwannomas: a systematic review, meta-analysis, and consensus statement on behalf of the EANS skull base section

Surgical management for large vestibular schwannomas: a systematic review, meta-analysis, and consensus statement on behalf of the EANS skull base section

Publié par La direction

SKULL BASE SATURDAY WEBINAR

20septembre
2020

SKULL BASE SATURDAY WEBINAR

SKULL BASE SATURDAY : SBN Sociedade Brasileira de Neurocirurgia

Publié par La direction

NEXT IRCAD COURSE : SKULL BASE 360° 26-29 January 2021

20septembre
2020

NEXT IRCAD COURSE : SKULL BASE 360° 26-29 January 2021

Specialties / Course calendar

Publié par La direction

UPCOMING WEBINAR : 7/10 17:00 pm CEST Craniocervical Junction Surgeries with Vertebral Artery Management

1octobre
2020

UPCOMING WEBINAR : 7/10 17:00 pm CEST Craniocervical Junction Surgeries with Vertebral Artery Management

Craniocervical Junction surgeries with vertebral artery management

Publié par La direction

The Neurosurgical Atlas Grand Rounds, Oct 26 2020 – Approach selection for complex skull base lesion – S Froelich

31octobre
2020

The Neurosurgical Atlas Grand Rounds, Oct 26 2020 – Approach selection for complex skull base lesion – S Froelich

The Neurosurgical Atlas Grand Rounds, Oct 26 2020 – Approach selection for complex skull base lesion – Lecture by Sébastien Froelich

Publié par La direction

Use of high dose cyproterone acetate and risk of intracranial meningioma in women: cohort study

19février
2021

Use of high dose cyproterone acetate and risk of intracranial meningioma in women: cohort study

Research Use of high dose cyproterone acetate and risk of intracranial meningioma in women: cohort study BMJ 2021

Publié par La direction

Endoscope-assisted far-lateral transcondylar approach for craniocervical junction chordomas: a retrospective case series and cadaveric dissection

13juin
2021

Endoscope-assisted far-lateral transcondylar approach for craniocervical junction chordomas: a retrospective case series and cadaveric dissection

Endoscope-assisted far-lateral transcondylar approach for craniocervical junction chordomas: a retrospective case series and cadaveric dissection

Publié par La direction

The Rostral Mucosa: The Door to Open and Close for Targeted Endoscopic Endonasal Approaches to the Clivus

13juin
2021

The Rostral Mucosa: The Door to Open and Close for Targeted Endoscopic Endonasal Approaches to the Clivus

The Rostral Mucosa: The Door to Open and Close for Targeted Endoscopic Endonasal Approaches to the Clivus

Publié par La direction

Focal Cortical Dysplasias, New advances for curing epilepsy, de Francine Chassoux et André Palmini

20juillet
2022

Focal Cortical Dysplasias, New advances for curing epilepsy, de Francine Chassoux et André Palmini

L’ouvrage marque le 50ème anniversaire de la première description de la dysplasie de Taylor, qui a révolutionné le monde de l’épilepsie et retrace l’histoire de l’évolution des concepts dans le monde de la recherche clinique et fondamentale. Les plus grands experts internationaux en épileptologie, neurophysiologie, neuropathologie, génétique, imagerie et neurochirurgie, ont conçu cet ouvrage et font le point sur les dernières avancées permettant de mieux connaître et traiter les épilepsies en rapport avec les dysplasies corticales focales. Ce dernier vous offre : • Des informations concrètes sur le meilleur usage de tous les outils disponibles et sur la prise en charge la plus efficace possible. • Les bases de possibles thérapies ciblées élaborées à partir des dernières avancées de la recherche génétique et moléculaire. Editorial Reviews Review Despite major advances in all fields, Focal Cortical Dysplasias remain a mystery. From the first description 50 years ago by Taylor and colleagues, nobody could suspect that they would become perhaps the most relevant etiology of focal epilepsies in patients of all ages, particularly those with refractory seizures. Therefore, there is an urgent need to better understand the mechanisms of epileptogenicity and the natural course of these brain developmental lesions, to […]

Publié par La direction

Intraoperative Mapping of Cognitive Networks : Which Tasks for Which Locations. De Emmanuel Mandonnet et Guillaume Herbet

20juillet
2022

Intraoperative Mapping of Cognitive Networks : Which Tasks for Which Locations. De Emmanuel Mandonnet et Guillaume Herbet

This book aims to give the state-of-the-art of intraoperative brain function mapping for resection of brain tumors in awake conditions, and to become a reference for acquiring the fundamental expertise necessary to select the right intraoperative task at the right time of the surgery. The chapters, all focused on a specific brain function, are divided in 4 parts: sensori-motor and visuo-spatial functions, language functions, higher-order functions, and prospects. Each chapter follows the same outline, including a brief review of the current knowledge about the networks sustaining the function in healthy subjects, the description of the intraoperative tasks designed to monitor the function, a review of the literature describing the deficits in that function after surgery, and a critical appraisal of the benefit provided by intraoperative mapping of that function. Comprehensive state-of the-art of intraoperative brain functions testing Common approach for all chapters Each chapter is written in tandem by a neurosurgeon and a neuropsychologist About the editors Emmanuel Mandonnet is currently full Professor of neurosurgery at Lariboisière hospital, University of Paris. After achieving a PhD in physics in 2000, he turned towards medical school and then residency in neurosurgery. His clinical and research activities focus on brain tumors, and […]

Publié par La direction

In vivo efficacy assessment of the CDK4/6 inhibitor palbociclib and the PLK1 inhibitor volasertib in human chordoma xenografts

28décembre
2022

In vivo efficacy assessment of the CDK4/6 inhibitor palbociclib and the PLK1 inhibitor volasertib in human chordoma xenografts

Abstract Background: Management of advanced chordomas remains delicate considering their insensitivity to chemotherapy. Homozygous deletion of the regulatory gene CDKN2A has been described as the most frequent genetic alteration in chordomas and may be considered as a potential theranostic marker. Here, we evaluated the tumor efficacy of the CDK4/6 inhibitor palbociclib, as well as the PLK1 inhibitor volasertib, in three chordoma patient-derived xenograft (PDX) models to validate and identify novel therapeutic approaches. Methods: From our chordoma xenograft panel, we selected three models, two of them harboring a homozygous deletion of CDKN2A/2B genes, and the last one a PBRM1 pathogenic variant (as control). For each model, we tested the palbociclib and volasertib drugs with pharmacodynamic studies together with RT-PCR and RNAseq analyses. Results: For palbociclib, we observed a significant tumor response for one of two models harboring the deletion of CDKN2A/2B (p = 0.02), and no significant tumor response in the PBRM1-mutated PDX; for volasertib, we did not observe any response in the three tested models. RT-PCR and RNAseq analyses showed a correlation between cell cycle markers and responses to palbociclib; finally, RNAseq analyses showed a natural enrichment of the oxidative phosphorylation genes (OxPhos) in the palbociclib-resistant PDX (p = […]

Publié par La direction

Combined petrosal approach for resection of a large left petroclival meningioma. Francesco Paglia, Lorenzo Giammattei, Paolo di Russo and Sebastien Froelich

28décembre
2022

Combined petrosal approach for resection of a large left petroclival meningioma. Francesco Paglia, Lorenzo Giammattei, Paolo di Russo and Sebastien Froelich

Petroclival meningiomas represent the most complex lesions in skull base surgery, being closely related to critical neurovascular structures. The combined petrosal approach allows a wide exposure of the petroclival region and provides multiple angles of attack, limiting brain retraction. The authors present the case of a 54-year-old man with a large left petroclival meningioma responsible for headaches, dysphagia, and trigeminal neuralgia. The lesion was resected using a combined petrosal approach. A progressive improvement of the preoperative symptoms was observed. Postoperative MRI showed a near-total resection of the tumor, along with reexpansion of the brainstem. The video can be found here:

Publié par La direction

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