Par-délà la dichotomie IRM positive / IRM negative : une évolution dans la prise en charge chirurgicale des maladies de Cushing
Management of Cushing’s disease (CD) has traditionally relied on a strict binary paradigm based on MRI findings (MRI-positive vs. MRI-negative cases). In a recent study published in Brain and Spine, the Neurosurgery team at Lariboisière Hospital proposes moving beyond this...
The Lariboisière Neurosurgery Team Discovers a New Robust MRI Sign Capable of Detecting Papillary Craniopharyngiomas
Published in the European Journal of Endocrinology, this retrospective study introduces a new MRI biomarker: the “polystyrene bead sign.” This novel radiological sign enables the preoperative identification of hypothalamic papillary craniopharyngiomas with high precision, paving the way for a radical...
Better predicting the aggressiveness of pituitary tumors through genomics
Published in the international journal Neuro-Oncology, which has a high impact factor (IF=13.2), our latest research offers a significant advancement in better understanding and predicting the behavior of pituitary adenomas (PitNETs), whose progression can vary greatly from one patient to...
a new minimally invasive concept and closure technique for endoscopic endonasal approaches
A new surgical technique developed by the neurosurgery team at Lariboisière Hospital, published in the Journal of Neurosurgery (2025), demonstrates that complex skull base tumors can be operated on through the nose in an even less invasive way — while...
High-Precision Radiosurgery Featured on France Télévisions
High-precision cerebral radiosurgery is gaining increased visibility among the general public. France Télévisions recently aired a report highlighting this innovative approach, with a focus on the ZAP-X technology used at Lariboisière Hospital (AP-HP). The feature showcases major advances in stereotactic...
Transorbital Eyebrow Lacrimal Keyhole Approach (TELKA)
Case highlight: A 64-year-old man with partial seizures underwent resection of a meningioma arising from the lateral wall of the cavernous sinus using a transorbital eyebrow lacrimal keyhole approach (TELKA). By removing the lip of the superolateral orbital rim (“lacrimal...
Specific focus on the basal dura for improving Cushing’s disease surgery: a cohort study
Background and objectives In Cushing’s disease, the rate of endocrine remission after surgery reaches about 80% in expert centers. However, due to the tumor’s ability to invade surrounding dural structures, hypercortisolism persists in 20% of patients or recurs in 15%....
Cog-First: Standardization of a Tablet-Based Self-Administered Cognitive Screening
Background Acquired brain injuries can lead to subtle cognitive impairments that are often difficult to detect, yet significantly influence long-term functional outcomes. Cog-First was developed as a self-administered, tablet-based cognitive screening tool designed to evaluate executive function, memory, and attention...
Endoscopic surgery for acromegaly: results from a large French-Italian study (25 years of experience)
Introduction Acromegaly is a rare condition caused by excessive growth hormone secretion, usually due to a benign pituitary tumor (adenoma). The standard treatment is endonasal endoscopic surgery, which allows removal of the tumor through the nose using a camera. A...
Oral contraceptives and risk of intracranial meningioma: insights from a French nationwide study
Introduction A recent case-control study based on the French National Health Data System (SNDS) assessed the association between the use of progestin-only oral contraceptives and the risk of intracranial meningioma requiring surgery. This large-scale analysis, including more than 92,000 women...