Surgical management for large vestibular schwannomas: a systematic review, meta-analysis, and consensus statement on behalf of the EANS skull base section
Petroclival meningiomas: the risk of post-operative cranial nerve deficits among different surgical approaches—a systematic review and meta-analysis, Acta Neurochirurgica (2020)
MICROSCOPIC and ENDOSCOPIC – APPROACHES to the SKULL BASE TRAINING on ANATOMICAL SPECIMEN [pdf-embedder url= »https://www.neurochirurgie-lariboisiere.com/wp-content/uploads/2016SB1050823-2.pdf »]
Mayfield & Foundation UC Department of Neurosurgery cordially invite you to the 6th annual Keller Lectureship in surgical neuroanatomy & research. [pdf-embedder url= »https://www.neurochirurgie-lariboisiere.com/wp-content/uploads/eveKellerLect2017.pdf » title= »_eveKellerLect2017″]
Cochlear congratulates UniversityHospital Zürich on 100 years ORL. Working together in partnership is how breakthroughs are achieved. USZ has helped countless people directly and indirectly through their commitment to always furthering ideas in research and surgery. Cochlear is proud to celebrate this achievement and looks forward to furthering research together in partnership for many years to come. [pdf-embedder url= »https://www.neurochirurgie-lariboisiere.com/wp-content/uploads/Program-100-years-ENT-departement.pdf » title= »Program 100 years ENT departement »]
Skull base neurosurgery course Trans-petrosal approaches: anterior and posterior petrosal, combined approach Orbito-zygomatic approach, clinoidectomy and cavernous sinus Live surgery
The Posterior Transpetrosal Approach in a Case of Large Retrochiasmatic Craniopharyngioma: Operative Video and Technical Nuances. Labidi M, Watanabe K, Loit MP, Hanakita S, Froelich S.
Endoscopic Endonasal Approach to the Anteromedial Temporal Fossa and Mobilization of the Lateral Wall of the Cavernous Sinus Through the Inferior Orbital Fissure and V1-V2 Corridor: An Anatomic Study and Clinical Considerations Hanakita S, Chang WC, Watanabe K, Ronconi D, Labidi M, Park HH, Oyama K, Bernat AL, Froelich S. V1V2
Resection of an Optic Canal Meningioma through a Contralateral Subfrontal Approach with Endoscopic Assistance: A 2D Operative Video. Labidi M, Watanabe K, Bernat AL, Hanakita S, Froelich S
2018 Sep;117:208-220. The Chopsticks Technique for Endoscopic Endonasal Surgery-Improving Surgical Efficiency and Reducing the Surgical Footprint. Labidi M, Watanabe K, Hanakita S, Park HH, Bouazza S, Bernat AL, Froelich S.
Regression of Giant Olfactory Groove Meningioma and Complete Visual Acuity Recovery after Discontinuation of Cyproterone Acetate. Bernat AL, Bonnin S, Labidi M, Aldahak N, Bresson D, Bouazza S, Froelich S
Le service de Neurochirurgie dispose depuis Novembre 2019 d’un scanner intra-opératoire. Cette technologie nouvelle au bloc opératoire permettra Pour la chirurgie intra-crânienne et de la base du crâne : de réduire au maximum le traumatisme chirurgical en utilisant des voies d’abord mini-invasives ciblées, d’améliorer la précision du geste chirurgical, de biopsier des lésions profondes de manière plus sûr, sous contrôle de l’image, d’améliorée la qualité de l’exérèse des tumeurs cérébrales et de la base du crâne, de rassurer de l’exclusion complète de certaines lesions vasculaires complexes, De controler la qualité d’une résection et l’absence de complication en post-opératoire immédiat avant la sortie de salle d’opération. Pour la chirurgie rachidienne : d’utiliser des voies d’accès ciblées, mini-invasives, moins traumatisantes, de réaliser des vissage (Arthrodèse – Ostéosynthèse) par voie per-cutanée, de rendre le geste chirurgical plus sûr.
From the Occipital Condyle to the Sphenoid Sinus: Extradural Extension of the Far Lateral Transcondylar Approach with Endoscopic Assistance ValentinaTardivo – MoujahedLabidi – ThibaultPasseri – Anne LaureBernat – FrancescoZenga – EduardVoormolen – NicolasPenet – SebastienFroelich.
Surmonter l’obstacle de la langue dans la chirurgie des tumeurs cérébrales en condition éveillée chez les migrants Sylvie Aubrun Isabelle Poisson Marion Barberis Chadia Draou Mariane Toure Catarina Madadaki Sébastien Froelich Etienne Gayat Emmanuel Mandonnet
Petroclival meningiomas: the risk of post-operative cranial nerve deficits among different surgical approaches—a systematic review and meta-analysis, Acta Neurochirurgica (2020)
Neurochirurgie guidée par l’image – Presentation du Pr Emmanuel Mandonnet au Collège de France – 27 mai 2014 Au cours de cet exposé, nous analyserons comment différents modèles biomathématiques de l’évolution des gliomes intracérébraux et de leur interaction avec le fonctionnement cérébral peuvent – ou pourront dans un futur proche – aider le neurochirurgien aux différentes étapes de la prise en charge du patient. En pré-opératoire, le modèle de croissance tumorale de prolifération-diffusion, alimenté par les IRM consécutives d’un patient, permet de déterminer la cinétique de croissance individuelle, élément fondamental dans la prise de décision opératoire. D’autre part, l’atlas de résécabilité fonctionnelle – construit à partir des résidus postopératoires de séries de patients opérés dans des centres de références et ayant pour but de pouvoir estimer objectivement si la tumeur d’un patient est opérable ou non – fournit un outil privilégié pour homogénéiser les stratégies de prise en charge entre différentes institutions. Pendant l’opération, le chirurgien s’aide de la neuronavigation comme d’un GPS intra-cérébral. Mais le « brain shift », généré par l’effondrement du cerveau au fur et à mesure de l’exérèse, limite considérablement la précision de cet outil (jusqu’à 1 cm de décalage). Des algorithmes de correction en temps réel, prenant en […]
Surgical management for large vestibular schwannomas: a systematic review, meta-analysis, and consensus statement on behalf of the EANS skull base section
L’ouvrage marque le 50ème anniversaire de la première description de la dysplasie de Taylor, qui a révolutionné le monde de l’épilepsie et retrace l’histoire de l’évolution des concepts dans le monde de la recherche clinique et fondamentale. Les plus grands experts internationaux en épileptologie, neurophysiologie, neuropathologie, génétique, imagerie et neurochirurgie, ont conçu cet ouvrage et font le point sur les dernières avancées permettant de mieux connaître et traiter les épilepsies en rapport avec les dysplasies corticales focales. Ce dernier vous offre : • Des informations concrètes sur le meilleur usage de tous les outils disponibles et sur la prise en charge la plus efficace possible. • Les bases de possibles thérapies ciblées élaborées à partir des dernières avancées de la recherche génétique et moléculaire. Editorial Reviews Review Despite major advances in all fields, Focal Cortical Dysplasias remain a mystery. From the first description 50 years ago by Taylor and colleagues, nobody could suspect that they would become perhaps the most relevant etiology of focal epilepsies in patients of all ages, particularly those with refractory seizures. Therefore, there is an urgent need to better understand the mechanisms of epileptogenicity and the natural course of these brain developmental lesions, to […]
This book aims to give the state-of-the-art of intraoperative brain function mapping for resection of brain tumors in awake conditions, and to become a reference for acquiring the fundamental expertise necessary to select the right intraoperative task at the right time of the surgery. The chapters, all focused on a specific brain function, are divided in 4 parts: sensori-motor and visuo-spatial functions, language functions, higher-order functions, and prospects. Each chapter follows the same outline, including a brief review of the current knowledge about the networks sustaining the function in healthy subjects, the description of the intraoperative tasks designed to monitor the function, a review of the literature describing the deficits in that function after surgery, and a critical appraisal of the benefit provided by intraoperative mapping of that function. Comprehensive state-of the-art of intraoperative brain functions testing Common approach for all chapters Each chapter is written in tandem by a neurosurgeon and a neuropsychologist About the editors Emmanuel Mandonnet is currently full Professor of neurosurgery at Lariboisière hospital, University of Paris. After achieving a PhD in physics in 2000, he turned towards medical school and then residency in neurosurgery. His clinical and research activities focus on brain tumors, and […]
Abstract Background: Management of advanced chordomas remains delicate considering their insensitivity to chemotherapy. Homozygous deletion of the regulatory gene CDKN2A has been described as the most frequent genetic alteration in chordomas and may be considered as a potential theranostic marker. Here, we evaluated the tumor efficacy of the CDK4/6 inhibitor palbociclib, as well as the PLK1 inhibitor volasertib, in three chordoma patient-derived xenograft (PDX) models to validate and identify novel therapeutic approaches. Methods: From our chordoma xenograft panel, we selected three models, two of them harboring a homozygous deletion of CDKN2A/2B genes, and the last one a PBRM1 pathogenic variant (as control). For each model, we tested the palbociclib and volasertib drugs with pharmacodynamic studies together with RT-PCR and RNAseq analyses. Results: For palbociclib, we observed a significant tumor response for one of two models harboring the deletion of CDKN2A/2B (p = 0.02), and no significant tumor response in the PBRM1-mutated PDX; for volasertib, we did not observe any response in the three tested models. RT-PCR and RNAseq analyses showed a correlation between cell cycle markers and responses to palbociclib; finally, RNAseq analyses showed a natural enrichment of the oxidative phosphorylation genes (OxPhos) in the palbociclib-resistant PDX (p = […]
Petroclival meningiomas represent the most complex lesions in skull base surgery, being closely related to critical neurovascular structures. The combined petrosal approach allows a wide exposure of the petroclival region and provides multiple angles of attack, limiting brain retraction. The authors present the case of a 54-year-old man with a large left petroclival meningioma responsible for headaches, dysphagia, and trigeminal neuralgia. The lesion was resected using a combined petrosal approach. A progressive improvement of the preoperative symptoms was observed. Postoperative MRI showed a near-total resection of the tumor, along with reexpansion of the brainstem. The video can be found here:
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