{"id":670139,"date":"2026-06-01T14:19:03","date_gmt":"2026-06-01T12:19:03","guid":{"rendered":"https:\/\/www.neurochirurgie-lariboisiere.com\/2026\/06\/01\/mieux-predire-lagressivite-des-tumeurs-hypophysaires-grace-a-la-genomique\/"},"modified":"2026-06-01T14:19:04","modified_gmt":"2026-06-01T12:19:04","slug":"mieux-predire-lagressivite-des-tumeurs-hypophysaires-grace-a-la-genomique","status":"publish","type":"post","link":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/2026\/06\/01\/mieux-predire-lagressivite-des-tumeurs-hypophysaires-grace-a-la-genomique\/","title":{"rendered":"Better predicting the aggressiveness of pituitary tumors through genomics"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"670139\" class=\"elementor elementor-670139 elementor-669979\">\n\t\t\t\t<div class=\"elementor-element elementor-element-25b52e1 e-flex e-con-boxed e-con e-parent\" data-id=\"25b52e1\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;pix_scale_in&quot;:&quot;none&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9343338 elementor-widget elementor-widget-text-editor\" data-id=\"9343338\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"adenome-page\">\n<div class=\"adenome-intro\">Published in the international journal <em>Neuro-Oncology<\/em>, which has a high impact factor (IF=13.2), our latest research offers a significant advancement in better understanding and predicting the behavior of pituitary adenomas (PitNETs), whose progression can vary greatly from one patient to another. Due to the rarity of aggressive forms and the heterogeneity of clinical practices, <span class=\"mc\">their classification remains complex<\/span>. <\/div>\n\n<section class=\"section-block\">\n<h3>Molecular signatures and tumor profiles<\/h3>\nBy integrating clinical, histopathological, and genomic data, we identified molecular signatures associated with unfavorable progression and highlighted distinct tumor profiles correlated with aggressiveness, particularly for <span class=\"mc\">corticotroph and lactotroph lineages<\/span>.\n<\/section>\n\n<section class=\"section-block\">\n<h3>A new histomolecular classification<\/h3>\nThese results have led to the proposal of a new &#8220;histomolecular&#8221; classification, combining biological and histological characteristics, with the objective of:\n<ul class=\"traitements-list\">\n     <li>Better estimating the risk of progression.<\/li>\n     <li>Helping to adapt patient management earlier in clinical practice.<\/li>\n<\/ul>\n<\/section>\n\n<section class=\"section-block\">\n<h3>Reference<\/h3>\n<ol class=\"publications-list\">\n     <li><span class=\"pub-authors\">Benanteur N, Villa C, Bioletto F, Birtolo MF, De Murat D, Masliah-Planchon J, Gravrand V, Lebib I, Benkhellat M, Boezennec R, Allassonni\u00e8re S, Letourneur F, Martin Y, Bonnet Serrano F, Jacob J, Calugaru V, Barat M, Dohan A, Arrondeau J, Huillard O, Raffin-Sanson ML, Emile JF, Raverot G, Lib\u00e9 R, Guignat L, Garcia C, Groussin L, Bertagna X, Gaillard S, Bertherat J, Jouinot A, Baussart B, Assi\u00e9 G.<\/span>\n Genomic characterization of aggressiveness in pituitary neuroendocrine tumors (PitNETs). \n <em>Neuro Oncol.<\/em> 2026 Apr 7:noag074. doi: 10.1093\/neuonc\/noag074. \n     <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41955313\/\" target=\"_blank\" rel=\"noopener\">View source on PubMed \u27a4<\/a><\/li>\n<\/ol>\n<\/section>\n<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Published in the international journal Neuro-Oncology, which has a high impact factor (IF=13.2), our latest research offers a significant advancement in better understanding and predicting the behavior of pituitary adenomas (PitNETs), whose progression can vary greatly from one patient to&#8230;<\/p>\n","protected":false},"author":5,"featured_media":669990,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-670139","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/posts\/670139","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/comments?post=670139"}],"version-history":[{"count":1,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/posts\/670139\/revisions"}],"predecessor-version":[{"id":670140,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/posts\/670139\/revisions\/670140"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/media\/669990"}],"wp:attachment":[{"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/media?parent=670139"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/categories?post=670139"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/tags?post=670139"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}