{"id":4841,"date":"2022-12-28T13:06:29","date_gmt":"2022-12-28T12:06:29","guid":{"rendered":"https:\/\/www.neurochirurgie-lariboisiere.com\/?p=4841"},"modified":"2024-12-01T21:19:22","modified_gmt":"2024-12-01T20:19:22","slug":"in-vivo-efficacy-assessment-of-the-cdk4-6-inhibitor-palbociclib-and-the-plk1-inhibitor-volasertib-in-human-chordoma-xenografts","status":"publish","type":"post","link":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/2022\/12\/28\/in-vivo-efficacy-assessment-of-the-cdk4-6-inhibitor-palbociclib-and-the-plk1-inhibitor-volasertib-in-human-chordoma-xenografts\/","title":{"rendered":"In vivo efficacy assessment of the CDK4\/6 inhibitor palbociclib and the PLK1 inhibitor volasertib in human chordoma xenografts"},"content":{"rendered":"<p>\u00a0<\/p>\n<p class=\"p1\">Les chordomes avanc\u00e9s, insensibles \u00e0 la chimioth\u00e9rapie, sont souvent associ\u00e9s \u00e0 une d\u00e9l\u00e9tion homozygote du g\u00e8ne CDKN2A. Cette \u00e9tude \u00e9value l\u2019efficacit\u00e9 de l\u2019inhibiteur CDK4\/6, palbociclib, et de l\u2019inhibiteur PLK1, volasertib, sur trois mod\u00e8les de x\u00e9nogreffes de chordomes d\u00e9riv\u00e9s de patients.<\/p>\n<p class=\"p2\">\u2022<b>R\u00e9sultats<\/b> : Palbociclib a montr\u00e9 une r\u00e9ponse tumorale significative dans un mod\u00e8le avec la d\u00e9l\u00e9tion CDKN2A\/2B (p = 0.02) mais aucune dans les autres. Volasertib n\u2019a produit aucune r\u00e9ponse notable.<\/p>\n<p class=\"p2\">\u2022<b>Conclusion<\/b> : L\u2019inhibition CDK4\/6 est prometteuse pour les chordomes avec perte de CDKN2A\/2B, mais des \u00e9tudes suppl\u00e9mentaires sont n\u00e9cessaires pour explorer les m\u00e9canismes de r\u00e9sistance, notamment ceux li\u00e9s \u00e0 l\u2019enrichissement des g\u00e8nes OxPhos observ\u00e9.<\/p>\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Source (anglais): <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36505864\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36505864\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00a0 Les chordomes avanc\u00e9s, insensibles \u00e0 la chimioth\u00e9rapie, sont souvent associ\u00e9s \u00e0 une d\u00e9l\u00e9tion homozygote du g\u00e8ne CDKN2A. Cette \u00e9tude \u00e9value l\u2019efficacit\u00e9 de l\u2019inhibiteur CDK4\/6, palbociclib, et de l\u2019inhibiteur PLK1, volasertib, sur trois mod\u00e8les de x\u00e9nogreffes de chordomes d\u00e9riv\u00e9s de&#8230;<\/p>\n","protected":false},"author":4,"featured_media":4842,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[150],"tags":[],"class_list":["post-4841","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-teaching"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/posts\/4841","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/comments?post=4841"}],"version-history":[{"count":1,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/posts\/4841\/revisions"}],"predecessor-version":[{"id":15620,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/posts\/4841\/revisions\/15620"}],"wp:attachment":[{"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/media?parent=4841"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/categories?post=4841"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/tags?post=4841"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}