{"id":17302,"date":"2025-09-22T22:18:25","date_gmt":"2025-09-22T20:18:25","guid":{"rendered":"https:\/\/www.neurochirurgie-lariboisiere.com\/?p=17302"},"modified":"2026-03-30T10:33:04","modified_gmt":"2026-03-30T08:33:04","slug":"endoscopic-surgery-for-acromegaly-results-from-a-large-french-italian-study-25-years-of-experience","status":"publish","type":"post","link":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/2025\/09\/22\/endoscopic-surgery-for-acromegaly-results-from-a-large-french-italian-study-25-years-of-experience\/","title":{"rendered":"Endoscopic surgery for acromegaly: results from a large French-Italian study (25 years of experience)"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Introduction<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Acromegaly is a rare condition caused by excessive growth hormone secretion, usually due to a benign pituitary tumor (adenoma).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The standard treatment is endonasal endoscopic surgery, which allows removal of the tumor through the nose using a camera.<br><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">A large international study<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Two expert neurosurgical teams, in France and Italy, analyzed <strong>822 patients operated between 1998 and 2022<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This is one of the largest cohorts ever reported in acromegaly.<br><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Main results<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Overall remission rate: 63%<\/strong><\/li>\n\n\n\n<li>According to tumor type:\n<ul class=\"wp-block-list\">\n<li>Microadenomas (small, enclosed tumors): <strong>88% remission<\/strong><\/li>\n\n\n\n<li>Macroadenomas without major extension: <strong>70%<\/strong><\/li>\n\n\n\n<li>Invasive tumors (with cavernous sinus invasion): <strong>2%<\/strong><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Surgical complications were rare<\/strong>:\n<ul class=\"wp-block-list\">\n<li>Cerebrospinal fluid leak: 1%<\/li>\n\n\n\n<li>Meningitis: 0.6%<\/li>\n\n\n\n<li>Other complications: \u22641%<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>New hormonal deficits<\/strong> after surgery: about <strong>3% of patients<\/strong><\/li>\n\n\n\n<li><strong>Hormonal recurrence<\/strong> after initial remission: only <strong>4% of patients<\/strong>, on average 3 years after surgery<br><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Conclusion<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">This long-term study shows that:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Endoscopic pituitary surgery is <strong>safe and effective<\/strong> when performed in reference centers.<\/li>\n\n\n\n<li>Cure rates are highest for small tumors.<\/li>\n\n\n\n<li>Once hormone levels are normalized, <strong>long-lasting remission<\/strong> can be expected in most patients.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">source: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40965517\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/40965517\/<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Introduction Acromegaly is a rare condition caused by excessive growth hormone secretion, usually due to a benign pituitary tumor (adenoma). The standard treatment is endonasal endoscopic surgery, which allows removal of the tumor through the nose using a camera. A&#8230;<\/p>\n","protected":false},"author":5,"featured_media":10127,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1,152],"tags":[],"class_list":["post-17302","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research","category-neurosurgery"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/posts\/17302","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/comments?post=17302"}],"version-history":[{"count":2,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/posts\/17302\/revisions"}],"predecessor-version":[{"id":17322,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/posts\/17302\/revisions\/17322"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/media\/10127"}],"wp:attachment":[{"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/media?parent=17302"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/categories?post=17302"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/tags?post=17302"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}