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Microprolactinomas are typically treated with dopamine agonists. However, data on the outcomes of patients treated with surgery remain limited. This study presents a large series of patients who underwent pituitary surgery for microprolactinomas and evaluates the efficacy and safety of this approach.
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Between January 2008 and October 2020, 114 adult patients with microprolactinomas underwent surgery in a specialized neurosurgical center. The technique used was an endoscopic endonasal transsphenoidal approach. Patients included in the study had a microprolactinoma with no evident cavernous sinus invasion on MRI. Prolactin levels were measured before and after surgery.
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\ud83d\udd39\u00a0Median follow-up<\/strong>: 18.2 months (ranging from 2.8 to 155 months) For well-selected patients, pituitary surgery performed by a specialized team is an effective and safe alternative to dopamine agonists for the treatment of microprolactinomas.<\/p>\n","protected":false},"excerpt":{"rendered":" Introduction Microprolactinomas are typically treated with dopamine agonists. However, data on the outcomes of patients treated with surgery remain limited. This study presents a large series of patients who underwent pituitary surgery for microprolactinomas and evaluates the efficacy and safety…<\/p>\n","protected":false},"author":24,"featured_media":16236,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-16239","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/posts\/16239","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/comments?post=16239"}],"version-history":[{"count":1,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/posts\/16239\/revisions"}],"predecessor-version":[{"id":16242,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/posts\/16239\/revisions\/16242"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/media\/16236"}],"wp:attachment":[{"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/media?parent=16239"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/categories?post=16239"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/tags?post=16239"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\ud83d\udd39\u00a0Cure rate<\/strong>: 88% of patients achieved remission after surgery.
\ud83d\udd39\u00a0Disease-free survival rate<\/strong>: 90.9% at 1 year and 81% at 5 years.
\ud83d\udd39\u00a0Predictive factor for remission<\/strong>: Preoperative prolactin levels were a key indicator of surgical success. `
\ud83d\udd39\u00a0Rare postoperative complications<\/strong>: No severe pituitary deficiency was observed, with only one case of diabetes insipidus and one cerebrospinal fluid leakage, both successfully treated
.<\/p>\n\n\n\nConclusion<\/h3>\n\n\n\n