{"id":15995,"date":"2025-01-16T16:55:58","date_gmt":"2025-01-16T15:55:58","guid":{"rendered":"https:\/\/www.neurochirurgie-lariboisiere.com\/?p=15995"},"modified":"2025-01-16T17:05:24","modified_gmt":"2025-01-16T16:05:24","slug":"elementor-15995","status":"publish","type":"post","link":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/2025\/01\/16\/elementor-15995\/","title":{"rendered":"Prolonged use of chlormadinone acetate and risk of intracranial meningioma: A population\u2010based cohort study"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"15995\" class=\"elementor elementor-15995\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2a1a862 e-flex e-con-boxed e-con e-parent\" data-id=\"2a1a862\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;pix_scale_in&quot;:&quot;none&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c87ae2d elementor-widget elementor-widget-text-editor\" data-id=\"c87ae2d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<section id=\"ene16505-sec-0001\"><h3 class=\"pmc_sec_title\">Background and Purpose<\/h3><p>Chlormadinone acetate (CMA) is a synthetic progestin for which cases of intracranial meningioma have been reported following prolonged exposure.<\/p><\/section><section id=\"ene16505-sec-0002\"><h3 class=\"pmc_sec_title\">Method<\/h3><p>An observational cohort study was conducted based on the French national health data system. Women aged 10\u201070 years and who started CMA between 2007 and 2017 were included. Participants were considered to be exposed if they had received a cumulative dose &gt;360\u2009mg of CMA during the first 6\u2009months and very slightly exposed (control group) when they had received a cumulative dose \u2264360\u2009mg. The outcome was surgery or radiotherapy for one or more intracranial meningioma(s). Poisson models assessed the relative risk (RR) of meningioma.<\/p><\/section><section id=\"ene16505-sec-0003\"><h3 class=\"pmc_sec_title\">Results<\/h3><p>In total, 828,499 women were included: 469,976 in the exposed group (mean age 39.1\u2009years, SD 10.1) and 358,523 in the control group (38.3\u2009years, SD 11.0). Surgery or radiotherapy for intracranial meningioma between 2007 and 2017 was recorded for 164 and 104 women in the exposed and control groups, respectively. The incidence of meningioma was 18.5 and 6.8 per 100,000 person\u2010years for the exposed and control groups respectively (crude RR\u2009=\u20092.7, 95% confidence interval [CI] 2.1\u20133.5; age\u2010adjusted RR\u2009=\u20093.1, 95% CI 2.4\u20134.0). Meningioma incidence reached almost 47 cases\/100,000 person\u2010years in the most exposed group (&gt;8.64\u2009g), giving an age\u2010adjusted RR of 6.9, 95% CI 5.1\u20139.2, relative to the control group.<\/p><\/section><section id=\"ene16505-sec-0004\"><h3 class=\"pmc_sec_title\"><span style=\"color: #000080;\">Conclusions<\/span><\/h3><p>A strong dose\u2013effect relationship was observed between prolonged use of CMA and risk of meningiomas. As with other progestogens, meningiomas associated with CMA are more likely to be found at the base of the skull.<\/p><\/section>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Background and Purpose Chlormadinone acetate (CMA) is a synthetic progestin for which cases of intracranial meningioma have been reported following prolonged exposure. Method An observational cohort study was conducted based on the French national health data system. Women aged 10\u201070&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-15995","post","type-post","status-publish","format-standard","hentry","category-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/posts\/15995","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/comments?post=15995"}],"version-history":[{"count":20,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/posts\/15995\/revisions"}],"predecessor-version":[{"id":16018,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/posts\/15995\/revisions\/16018"}],"wp:attachment":[{"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/media?parent=15995"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/categories?post=15995"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/tags?post=15995"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}