{"id":8900,"date":"2024-04-08T11:24:46","date_gmt":"2024-04-08T09:24:46","guid":{"rendered":"http:\/\/www.neurochirurgie-lariboisiere.com\/chordoma\/"},"modified":"2026-03-23T15:40:02","modified_gmt":"2026-03-23T14:40:02","slug":"chordome","status":"publish","type":"page","link":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/healthcare\/skull-base-surgery\/chordome\/","title":{"rendered":"Chordoma"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"8900\" class=\"elementor elementor-8900 elementor-7097\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4276a0ed e-flex e-con-boxed e-con e-parent\" data-id=\"4276a0ed\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;pix_scale_in&quot;:&quot;none&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-41536705 elementor-widget elementor-widget-shortcode\" data-id=\"41536705\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\">\r\n    <style>\r\n    .bc-nav { display:flex; 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font-weight:700;\">Offre de soins :<\/span><div class=\"bc-dropdown\"><button class=\"bc-dropdown-btn\" onclick=\"bcToggle('bc-cat')\">Skull base surgery<\/button><div class=\"bc-dropdown-list\" id=\"bc-cat\"><a href=\"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/healthcare\/pituitary-surgery\/\">Pituitary surgery<\/a><a href=\"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/healthcare\/spine-surgery\/\">Spine surgery<\/a><a href=\"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/healthcare\/hinge-deformities\/\">Hinge deformities<\/a><a href=\"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/healthcare\/pain-surgery\/\">Pain surgery<\/a><a href=\"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/healthcare\/vascular-neurosurgery\/\">Vascular neurosurgery<\/a><a href=\"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/healthcare\/neuro-oncology\/\">Neuro-oncology<\/a><a href=\"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/healthcare\/epilepsy-surgery\/\">Epilepsy surgery<\/a><a href=\"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/healthcare\/craniopharyngioma\/\">Craniopharyngioma<\/a><a href=\"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/healthcare\/radiosurgery\/\">Radiosurgery<\/a><a href=\"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/healthcare\/skull-base-surgery\/\" class=\"current\">Skull base surgery<\/a><\/div><\/div><span style=\"color:#7AAAD4; margin:0 8px; font-size:13px;\">\u203a<\/span><div class=\"bc-dropdown\"><button class=\"bc-dropdown-btn active\" onclick=\"bcToggle('bc-sub')\">Chordoma<\/button><div class=\"bc-dropdown-list\" id=\"bc-sub\"><a href=\"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/healthcare\/skull-base-surgery\/what-is-skull-base-surgery\/\">What is the base of the skull?<\/a><a href=\"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/healthcare\/skull-base-surgery\/epidermoid-cystkyste-epidermoide\/\">Epidermoid cyst<\/a><a href=\"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/healthcare\/skull-base-surgery\/chondrosarcoma\/\">Chondrosarcoma<\/a><a href=\"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/healthcare\/skull-base-surgery\/chordome\/\" class=\"current\">Chordoma<\/a><a href=\"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/healthcare\/skull-base-surgery\/meningioma\/\">Meningioma<\/a><a href=\"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/healthcare\/skull-base-surgery\/neurinome-de-lacoustique\/\">Vestibular schwannoma<\/a><\/div><\/div><\/nav><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7c9ee886 e-flex e-con-boxed e-con e-parent\" data-id=\"7c9ee886\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;pix_scale_in&quot;:&quot;none&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7a93437c e-con-full e-flex e-con e-child\" data-id=\"7a93437c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;pix_scale_in&quot;:&quot;none&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3613064c elementor-widget elementor-widget-pix-vertical-tabs\" data-id=\"3613064c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"pix-vertical-tabs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"\"  ><div class=\"row pix-waiting pix_tabs_container\"><div class=\"col-12 col-md-4 d-inline-block\"><div class=\"sticky-top\" style=\"top:110px;\"><div class=\"nav pix_tabs_btns text-left flex-column nav-pills pix-pills-1\" role=\"tablist\" id=\"v-pills-tab\"  aria-orientation=\"vertical\" ><div class=\"nav-item\"><a class=\"nav-link pix-tabs-btn text-24 pix-px-25 d-flex align-items-center py-2 my-2 active font-weight-bold  secondary-font\" data-id=\"3613064c-7f6c346\" role=\"tab\" id=\"pix-tab-btn-3613064c-7f6c346\" data-toggle=\"pill\" href=\"#pix-tab-3613064c-7f6c346\"  aria-controls=\"pix-tab-3613064c-7f6c346\">What are chordomas?<\/a><\/div><div class=\"nav-item\"><a class=\"nav-link pix-tabs-btn text-24 pix-px-25 d-flex align-items-center py-2 my-2  font-weight-bold  secondary-font\" data-id=\"3613064c-40dc23d\" role=\"tab\" id=\"pix-tab-btn-3613064c-40dc23d\" data-toggle=\"pill\" href=\"#pix-tab-3613064c-40dc23d\"  aria-controls=\"pix-tab-3613064c-40dc23d\">Origin of chordomas?<\/a><\/div><div class=\"nav-item\"><a class=\"nav-link pix-tabs-btn text-24 pix-px-25 d-flex align-items-center py-2 my-2  font-weight-bold  secondary-font\" data-id=\"3613064c-4569fe2\" role=\"tab\" id=\"pix-tab-btn-3613064c-4569fe2\" data-toggle=\"pill\" href=\"#pix-tab-3613064c-4569fe2\"  aria-controls=\"pix-tab-3613064c-4569fe2\">Who's affected?<\/a><\/div><div class=\"nav-item\"><a class=\"nav-link pix-tabs-btn text-24 pix-px-25 d-flex align-items-center py-2 my-2  font-weight-bold  secondary-font\" data-id=\"3613064c-49fe413\" role=\"tab\" id=\"pix-tab-btn-3613064c-49fe413\" data-toggle=\"pill\" href=\"#pix-tab-3613064c-49fe413\"  aria-controls=\"pix-tab-3613064c-49fe413\">Where are chordomas located?<\/a><\/div><\/div><\/div><\/div><div class=\"col-12 col-md-8 d-inline-block\"><div class=\"pix_tabs_content\"><div class=\"tab-content \"><div class=\"tab-pane active fade show \" role=\"tabpanel\" id=\"pix-tab-3613064c-7f6c346\" data-bold=\"font-weight-bold\" data-italic=\"\" data-secondary=\"secondary-font\" data-id=\"3613064c-7f6c346\" data-icon=\"\" data-title=\"What are chordomas?\" aria-labelledby=\"pix-tab-3613064c-7f6c346\"><div class=\"adenome-page\">\n\n  <!-- INTRO -->\n  <div class=\"adenome-intro\">\n Chordomas are <span class=\"mc\">rare tumors<\/span> that develop in the bones of the <a href=\"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/healthcare\/skull-base-surgery\/what-is-skull-base-surgery\/\" target=\"_blank\" rel=\"noopener\">skull base<\/a> or the spine. These are complex lesions requiring specialized management by an experienced multidisciplinary team. Our team has <strong>one of the largest experiences worldwide<\/strong> in the management of chordomas.  \n  <\/div>\n\n  <!-- VID\u00c9O -->\n  <figure>\n    <a href=\"https:\/\/www.youtube.com\/watch?v=mzqgVH0N2kA\" target=\"_blank\" rel=\"noopener\">\n      <img decoding=\"async\" src=\"https:\/\/i.ytimg.com\/vi\/mzqgVH0N2kA\/sddefault.jpg\" alt=\"Chordoma, a rare bone cancer \u2014 Le Magazine de la sant\u00e9\" style=\"max-width:100%; height:auto;\">\n    <\/a>\n    <figcaption><em>Chordoma, a rare bone cancer \u2014 Le Magazine de la sant\u00e9 (YouTube video).<\/em><\/figcaption>\n  <\/figure>\n\n  <!-- SYMPT\u00d4MES -->\n  <section id=\"symptomes\" class=\"section-block\">\n    <h3>Symptoms<\/h3>\n    <p>Chordomas grow slowly, and symptoms are generally late. They vary depending on the location: <\/p>\n\n    <div class=\"types-grid\" style=\"grid-template-columns: 1fr 1fr 1fr;\">\n      <div class=\"type-card\">\n        <h4>Skull base<\/h4>\n Headaches, double vision, loss of vision or hearing, difficulty swallowing, hoarseness, gait disturbances, motor weakness.\n      <\/div>\n      <div class=\"type-card\">\n        <h4>Spine<\/h4>\n Pain, tingling, or a feeling of weakness in a limb.\n      <\/div>\n      <div class=\"type-card\">\n        <h4>Sacrum<\/h4>\n Often discovered late: pain, urinary disorders, or even urinary and fecal incontinence.\n      <\/div>\n    <\/div>\n  <\/section>\n\n  <!-- DIAGNOSTIC -->\n  <section id=\"diagnostic\" class=\"section-block\">\n    <h3>Diagnosis<\/h3>\n    <p>CT and, above all, <strong>MRI<\/strong> can identify the tumor. The very characteristic appearance of chordomas on MRI often makes it possible to strongly suspect the diagnosis. Specific MRI sequences are required\u2014because this is a rare tumor, radiological diagnosis requires <strong>experienced radiologists<\/strong>.  <\/p>\n  <\/section>\n\n  <!-- TYPES -->\n  <section id=\"types\" class=\"section-block\">\n    <h3>Types of chordomas<\/h3>\n    <p>The 2020 WHO classification defines three categories:<\/p>\n\n    <ol class=\"examens\">\n      <li>\n        <h4>Conventional chordoma<\/h4>\n        <p>Includes typical and chondroid chordomas. Represents the <strong>majority of cases<\/strong>. <\/p>\n      <\/li>\n      <li>\n        <h4>Dedifferentiated chordoma<\/h4>\n        <p>Very rare, more aggressive. Most often occurs during the course of a known chordoma, particularly in the event of recurrence after irradiation. <\/p>\n      <\/li>\n      <li>\n        <h4>Poorly differentiated chordoma<\/h4>\n        <p>A new entity defined by loss of the INI1 protein (deletion of the SMARCB1 gene). More aggressive than conventional chordoma, but may respond to <strong>targeted medical treatments<\/strong>. <\/p>\n      <\/li>\n    <\/ol>\n\n    <figure>\n      <img decoding=\"async\" src=\"https:\/\/www.neurochirurgie-lariboisiere.com\/wp-content\/uploads\/Chordome-5.jpg\" alt=\"Microscopic view of a fragment of conventional chordoma\" style=\"max-width:100%; height:auto;\">\n      <figcaption><em>Microscopic view of a fragment of conventional chordoma (HES staining, x400 magnification). The vacuolated cells (red arrow) correspond to physaliphorous cells typical of chordomas. <\/em><\/figcaption>\n    <\/figure>\n  <\/section>\n\n  <!-- TRAITEMENT -->\n  <section id=\"traitement\" class=\"section-block\">\n    <h3>Treatment<\/h3>\n\n    <h4>Multidisciplinary approach<\/h4>\n    <p>A multidisciplinary approach is <strong>essential<\/strong>. Our department organizes a <strong>monthly national MDT meeting \u201cChordomas and Chondrosarcomas\u201d<\/strong>, enabling all French teams to present their cases and discuss therapeutic options. We collaborate in particular with:  <\/p>\n\n    <ul style=\"margin-bottom: 20px;\">\n      <li>The Neuroradiology Department at Lariboisi\u00e8re Hospital<\/li>\n      <li>The <a href=\"https:\/\/curie.fr\/liste\/centre-de-protontherapie\" target=\"_blank\" rel=\"noopener\">Orsay proton therapy department<\/a> (Institut Curie \u2014 Dr Hamid Mammar, Dr Valentin Calugaru)<\/li>\n      <li>Necker Hospital \u2014 pediatric neurosurgery department (Prof. Kevin Beccaria)<\/li>\n    <\/ul>\n\n    <div style=\"text-align:center; margin-bottom: 32px;\">\n      <a href=\"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/service\/multidisciplinary-meetings-rcp\/\" target=\"_blank\" rel=\"noopener\" style=\"display:inline-block; background:var(--bleu-accent); color:white; padding:12px 24px; border-radius:5px; font-weight:bold; text-decoration:none; font-size:0.9em; letter-spacing:0.03em;\">\n SKULL BASE MDT \u2014 CHORDOMAS \u2192\n      <\/a>\n    <\/div>\n\n    <ul class=\"traitements-list\">\n      <li>\n        <strong>Biopsy<\/strong>\n Rarely necessary at the skull base and cervical spine. At the lumbar level or in the sacrum, it may be performed to confirm the diagnosis\u2014always by trained teams, under strict conditions to avoid tumor seeding along the biopsy tract. \n      <\/li>\n      <li>\n        <strong>Surgery<\/strong>\n Must be performed in <strong>experienced centers<\/strong>. Incomplete treatment in an insufficiently specialized center can compromise any subsequent surgical reoperation. The goal is complete resection while preserving neural structures. At the sacrum, <em>en bloc<\/em> resection (without crossing the tumor capsule) is the optimal technique to maximize the chances of cure.   \n      <\/li>\n      <li>\n        <strong>Proton therapy \/ Radiotherapy<\/strong>\n Chordomas have a strong tendency for local recurrence\u2014surgery must therefore be complemented by <strong>high-dose radiotherapy<\/strong>. The reference technique is <a href=\"https:\/\/curie.fr\/liste\/centre-de-protontherapie\" target=\"_blank\" rel=\"noopener\">proton therapy (Orsay center)<\/a>. <a href=\"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/radiosurgery\/\" target=\"_blank\" rel=\"noopener\">Radiosurgery<\/a> may be offered for small-volume lesions or small localized recurrences.  \n      <\/li>\n      <li>\n        <strong>Chemotherapy<\/strong>\n In the event of recurrence, reoperation is most often proposed first. If a further recurrence occurs or if surgery is not possible, chemotherapy may be considered. <strong>Clinical trials<\/strong> are underway to evaluate new treatments.  \n      <\/li>\n    <\/ul>\n  <\/section>\n\n  <!-- \u00c9VOLUTION -->\n  <section id=\"evolution\" class=\"section-block\">\n    <h3>Course and prognosis<\/h3>\n    <p>The course is often favorable but requires <span class=\"mc\">aggressive treatment combining surgery and proton therapy<\/span>. Each patient\u2019s prognosis is unique and depends on age, the type of chordoma, tumor volume at diagnosis, location, and whether resection is complete. <\/p>\n\n    <p>Approximately <strong>30% of patients<\/strong> develop metastases during the course of the disease, most often late (lungs, liver, subcutaneous tissue, lymph nodes). They are rarely present at the initial diagnosis and are often well tolerated. <\/p>\n  <\/section>\n\n  <!-- LIENS UTILES -->\n  <section id=\"liens\" class=\"section-block\">\n    <h3>Useful links<\/h3>\n    <div style=\"display:flex; gap:32px; align-items:center; flex-wrap:wrap; margin-top:12px;\">\n      <a href=\"http:\/\/chordome.org\" target=\"_blank\" rel=\"noopener noreferrer\">\n        <img decoding=\"async\" src=\"https:\/\/www.neurochirurgie-lariboisiere.com\/wp-content\/uploads\/avac-300x184.jpg\" alt=\"AVAC Association \u2014 chordome.org\" width=\"200\" style=\"border-radius:4px;\">\n      <\/a>\n      <a href=\"https:\/\/www.chordomafoundation.org\/\" target=\"_blank\" rel=\"noopener noreferrer\">\n        <img decoding=\"async\" src=\"https:\/\/www.neurochirurgie-lariboisiere.com\/wp-content\/uploads\/CF_Logo_4C_Horizontal-web.png\" alt=\"Chordoma Foundation\" width=\"180\" style=\"border-radius:4px;\">\n      <\/a>\n    <\/div>\n  <\/section>\n\n  <!-- FOOTER -->\n  <div class=\"adenome-footer\">\n    <strong>General medical information:<\/strong> This page provides educational information and does not replace a medical consultation. No health decisions should be made without personalized medical advice.\n  <\/div>\n\n<\/div><\/div><div class=\"tab-pane   show \" role=\"tabpanel\" id=\"pix-tab-3613064c-40dc23d\" data-bold=\"font-weight-bold\" data-italic=\"\" data-secondary=\"secondary-font\" data-id=\"3613064c-40dc23d\" data-icon=\"\" data-title=\"Origin of chordomas?\" aria-labelledby=\"pix-tab-3613064c-40dc23d\"><p>Chordomas develop from residues of the notochord. The notochord is an embryonic structure that forms the axis of development of the fetus and participates in the development of the spinal column.<\/p><p>The notochord disappears when the fetus is around 8 weeks old, but some notochord cells do not disappear and persist in the bones of the spine and skull base. The reason why some of these cells develop into chordomas is not yet known, but research is progressing.<\/p><p>The vast majority of chordomas occur randomly and are not hereditary. As with all tumors, there are certain genetic changes in chordoma cells. <br><br>For example, over 95% of individuals with a chordoma have an abnormality in the DNA sequence of a gene called brachyuria. This anomaly increases the risk of developing a chordoma, but does not in itself cause a chordoma.<\/p><\/div><div class=\"tab-pane   show \" role=\"tabpanel\" id=\"pix-tab-3613064c-4569fe2\" data-bold=\"font-weight-bold\" data-italic=\"\" data-secondary=\"secondary-font\" data-id=\"3613064c-4569fe2\" data-icon=\"\" data-title=\"Who's affected?\" aria-labelledby=\"pix-tab-3613064c-4569fe2\"><p>There are around 80 new cases in France every year. Indeed, at any given time, fewer than one person in 100,000 is living with a chordoma (prevalence).<br>Chordoma is most often diagnosed in people aged 50\u201360, but it can occur at any age.<br>In addition, there is a slight male predominance, with a ratio of about 2 men to 1 woman.<br>Familial chordomas are very rare, and only a few familial cases have been identified.<\/p><\/div><div class=\"tab-pane   show \" role=\"tabpanel\" id=\"pix-tab-3613064c-49fe413\" data-bold=\"font-weight-bold\" data-italic=\"\" data-secondary=\"secondary-font\" data-id=\"3613064c-49fe413\" data-icon=\"\" data-title=\"Where are chordomas located?\" aria-labelledby=\"pix-tab-3613064c-49fe413\"><p>Around 40% of chordomas form in the skull base and craniocervical hinge, 30% in the bones of the mobile spine and around 40% in the sacrum.<\/p><p>Chordomas of the skull base are generally located in a bone called the clivus. These are deep-seated lesions, generally located in the center of the skull, close to critical structures, which are difficult to access and complex to treat. Skull base chordomas are sometimes called brain tumors because they can grow inwards from the skull towards the brain, but they don't actually develop from brain cells.<\/p><p>They can also occur in the cervical spine and lumbar spine (lower back). These zones make up the \"mobile\" column. Locations in the thoracic spine are rarer.<\/p><p>In 40% of cases, they also occur in the sacrum. They are located more or less high on the sacrum and are more or less complex to remove, depending on the relationship with the nerves to the sphincters and the rectum in front.<\/p><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-182ebbe2 e-flex e-con-boxed e-con e-parent\" data-id=\"182ebbe2\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;pix_scale_in&quot;:&quot;none&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-4955c47 e-con-full e-flex e-con e-child\" data-id=\"4955c47\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;pix_scale_in&quot;:&quot;none&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-1f23bc81 e-con-full e-flex e-con e-child\" data-id=\"1f23bc81\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;pix_scale_in&quot;:&quot;none&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-70d35da2 elementor-invisible elementor-widget elementor-widget-pix-text\" data-id=\"70d35da2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"pix-text.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"pix-el-text w-100 text-center \" ><p class=\"text-sm resp-option text-white text-center font-weight-bold secondary-font\" ><span class=\"text-white animate-in d-inline-block\" data-anim-delay=\"0\" data-anim-type=\"fade-in\">Guide<\/span><\/p><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7398e97e elementor-widget elementor-widget-pix-sliding-text\" data-id=\"7398e97e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"pix-sliding-text.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div id=\"el-7398e97e\" class=\"mb-3 text-center \"><div class=\"d-inline-block\" style=\"max-width:600px;\"><h1 class=\"mb-32 pix-sliding-headline-2 animate-in font-weight-bold secondary-font \" data-anim-type=\"pix-sliding-text\" data-class=\"secondary-font text-white\" style=\"\"><span class=\"slide-in-container\"><span class=\"pix-sliding-item pix-sliding-letter secondary-font text-white\" style=\"transition-delay: 0ms;transition-duration: 800ms;\">P<\/span><span class=\"pix-sliding-item pix-sliding-letter secondary-font text-white\" style=\"transition-delay: 9.0909090909091ms;transition-duration: 800ms;\">r<\/span><span class=\"pix-sliding-item pix-sliding-letter secondary-font text-white\" style=\"transition-delay: 18.181818181818ms;transition-duration: 800ms;\">o<\/span><span class=\"pix-sliding-item pix-sliding-letter secondary-font text-white\" style=\"transition-delay: 27.272727272727ms;transition-duration: 800ms;\">s<\/span><span class=\"pix-sliding-item pix-sliding-letter secondary-font text-white\" style=\"transition-delay: 36.363636363636ms;transition-duration: 800ms;\">p<\/span><span class=\"pix-sliding-item pix-sliding-letter secondary-font text-white\" style=\"transition-delay: 45.454545454545ms;transition-duration: 800ms;\">e<\/span><span class=\"pix-sliding-item pix-sliding-letter secondary-font text-white\" style=\"transition-delay: 54.545454545455ms;transition-duration: 800ms;\">c<\/span><span class=\"pix-sliding-item pix-sliding-letter secondary-font text-white\" style=\"transition-delay: 63.636363636364ms;transition-duration: 800ms;\">t<\/span><span class=\"pix-sliding-item pix-sliding-letter secondary-font text-white\" style=\"transition-delay: 72.727272727273ms;transition-duration: 800ms;\">i<\/span><span class=\"pix-sliding-item pix-sliding-letter secondary-font text-white\" style=\"transition-delay: 81.818181818182ms;transition-duration: 800ms;\">v<\/span><span class=\"pix-sliding-item pix-sliding-letter secondary-font text-white\" style=\"transition-delay: 90.909090909091ms;transition-duration: 800ms;\">e<\/span><\/span> <span class=\"slide-in-container\"><span class=\"pix-sliding-item pix-sliding-letter secondary-font text-white\" style=\"transition-delay: 100ms;transition-duration: 800ms;\">P<\/span><span class=\"pix-sliding-item pix-sliding-letter secondary-font text-white\" style=\"transition-delay: 112.5ms;transition-duration: 800ms;\">a<\/span><span class=\"pix-sliding-item pix-sliding-letter secondary-font text-white\" style=\"transition-delay: 125ms;transition-duration: 800ms;\">t<\/span><span class=\"pix-sliding-item pix-sliding-letter secondary-font text-white\" style=\"transition-delay: 137.5ms;transition-duration: 800ms;\">i<\/span><span class=\"pix-sliding-item pix-sliding-letter secondary-font text-white\" style=\"transition-delay: 150ms;transition-duration: 800ms;\">e<\/span><span class=\"pix-sliding-item pix-sliding-letter secondary-font text-white\" style=\"transition-delay: 162.5ms;transition-duration: 800ms;\">n<\/span><span class=\"pix-sliding-item pix-sliding-letter secondary-font text-white\" style=\"transition-delay: 175ms;transition-duration: 800ms;\">t<\/span><span class=\"pix-sliding-item pix-sliding-letter secondary-font text-white\" style=\"transition-delay: 187.5ms;transition-duration: 800ms;\">s<\/span><\/span> <\/h1><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6dd3bd87 elementor-invisible elementor-widget elementor-widget-pix-text\" data-id=\"6dd3bd87\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"pix-text.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"pix-el-text w-100 text-center \" ><div class=\"d-inline-block\" style=\"max-width:500px;\"><p class=\" resp-option text-light-opacity-7 text-center \" ><span class=\"text-light-opacity-7 animate-in d-inline-block\" data-anim-delay=\"150\" data-anim-type=\"fade-in-down\">Your stay is our priority, and we have established a patient pathway program for your surgical schedule, admission\n and intervention, through to your discharge. Please do not hesitate to contact us if you have any questions.<\/span><\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-74504d5d elementor-widget elementor-widget-pix-button\" data-id=\"74504d5d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"pix-button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<a href=\"https:\/\/8f1e-11d1aafe0b85.wptiger.fr\/votre-sejour-parcourspatient\/\" class=\"btn m-0      text-heading-default btn-white d-inline-flex align-items-center pix-hover-item       animate-in btn-md\" data-anim-type=\"fade-in-down\" data-anim-delay=\"300\" target=\"_blank\" rel=\"noopener\"><span class=\"font-weight-bold \" >Your stay<\/span><svg class=\"pixfort-icon font-weight-bold  pix-hover-right  ml-2\" width=\"24\" height=\"24\"  data-name=\"Duotone\/pixfort-icon-arrow-right-circle-2\" viewBox=\"2 2 20 20\"><g fill=\"none\" fill-rule=\"evenodd\"><path fill=\"var(--pf-icon-color)\" fill-opacity=\".25\" d=\"M12,2 C6.4771525,2 2,6.4771525 2,12 C2,17.5228475 6.4771525,22 12,22 C17.5228475,22 22,17.5228475 22,12 C22,6.4771525 17.5228475,2 12,2 Z\"\/><path fill=\"var(--pf-icon-color)\" d=\"M11.2071068,7.29289322 L15.2071068,11.2928932 C15.5976311,11.6834175 15.5976311,12.3165825 15.2071068,12.7071068 L11.2071068,16.7071068 C10.8165825,17.0976311 10.1834175,17.0976311 9.79289322,16.7071068 C9.40236893,16.3165825 9.40236893,15.6834175 9.79289322,15.2928932 L13.085,12 L9.79289322,8.70710678 C9.40236893,8.31658249 9.40236893,7.68341751 9.79289322,7.29289322 C10.1834175,6.90236893 10.8165825,6.90236893 11.2071068,7.29289322 Z\"\/><\/g><\/svg><\/a>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-98423a1 e-con-full e-flex e-con e-child\" data-id=\"98423a1\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;pix_scale_in&quot;:&quot;none&quot;}\">\n\t\t<div class=\"pix-base-transition elementor-element elementor-element-11bd5602 e-con-full bg-dark-blur e-flex e-con e-child\" data-id=\"11bd5602\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;pix_scale_in&quot;:&quot;none&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6ce682d2 elementor-widget elementor-widget-pix-feature\" data-id=\"6ce682d2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"pix-feature.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<a href=\"\/patient\/informations-pratiques\/\" ><div id=\"pix-feature-6ce682d2\" class=\"pix-feature-el  text-custom \"><div class=\"pix-feature-icon d-inline-block mw-100 text-white \"   style=\"aspect-ratio:1\/1 !important;position:relative;text-align:center;font-size:1px;line-height:1px;\"><svg class=\"pixfort-icon \" width=\"24\" height=\"24\"  data-name=\"Duotone\/pixfort-icon-information-circle-1\" viewBox=\"2 2 20 20\"><g fill=\"none\" fill-rule=\"evenodd\"><path fill=\"var(--pf-icon-color)\" fill-opacity=\".25\" d=\"M12,2 C6.4771525,2 2,6.4771525 2,12 C2,17.5228475 6.4771525,22 12,22 C17.5228475,22 22,17.5228475 22,12 C22,6.4771525 17.5228475,2 12,2 Z\"\/><path fill=\"var(--pf-icon-color)\" d=\"M12.15,8.475 L11.85,8.475 C11.2977153,8.475 10.85,8.02728475 10.85,7.475 L10.85,7.025 C10.85,6.47271525 11.2977153,6.025 11.85,6.025 L12.15,6.025 C12.7022847,6.025 13.15,6.47271525 13.15,7.025 L13.15,7.475 C13.15,8.02728475 12.7022847,8.475 12.15,8.475 Z M12,18 C12.5522847,18 13,17.5522847 13,17 L13,10.5 C13,9.94771525 12.5522847,9.5 12,9.5 C11.4477153,9.5 11,9.94771525 11,10.5 L11,17 C11,17.5522847 11.4477153,18 12,18 Z\"\/><\/g><\/svg><\/div><h5 class=\"pix-feature-title  font-weight-bold   text-white \" style=\"padding-top:20px;\"  >Practical Information<\/h5><div class=\"pix-feature-content text-body-default      \" style=\"\"  ><\/div><\/div><\/a>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"pix-base-transition elementor-element elementor-element-41e47791 e-con-full bg-dark-blur e-flex e-con e-child\" data-id=\"41e47791\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;pix_scale_in&quot;:&quot;none&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7c5b56c elementor-widget elementor-widget-pix-feature\" data-id=\"7c5b56c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"pix-feature.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<a href=\"\/prendre-un-rdv\/\" ><div id=\"pix-feature-7c5b56c\" class=\"pix-feature-el  text-custom \"><div class=\"pix-feature-icon d-inline-block mw-100 text-white \"   style=\"aspect-ratio:1\/1 !important;position:relative;text-align:center;font-size:1px;line-height:1px;\"><svg class=\"pixfort-icon \" width=\"24\" height=\"24\"  data-name=\"Duotone\/pixfort-icon-calendar-3\" viewBox=\"2 2 20 20\"><g fill=\"none\" fill-rule=\"evenodd\"><path fill=\"var(--pf-icon-color)\" fill-opacity=\".25\" d=\"M2,10 L2,18.7857143 C2,20.5609153 3.34314575,22 5,22 L19,22 C20.6568542,22 22,20.5609153 22,18.7857143 L22,10 L2,10 Z\"\/><path fill=\"var(--pf-icon-color)\" d=\"M14,17 C14.5522847,17 15,17.4477153 15,18 C15,18.5522847 14.5522847,19 14,19 L7,19 C6.44771525,19 6,18.5522847 6,18 C6,17.4477153 6.44771525,17 7,17 L14,17 Z M17,13 C17.5522847,13 18,13.4477153 18,14 C18,14.5522847 17.5522847,15 17,15 L7,15 C6.44771525,15 6,14.5522847 6,14 C6,13.4477153 6.44771525,13 7,13 L17,13 Z M19,4 C20.6568542,4 22,5.34314575 22,7 L22,9 L2,9 L2,7 C2,5.34314575 3.34314575,4 5,4 L6,4 L6,6 C6,6.49091978 6.17687516,6.94052815 6.47037492,7.28857455 L6.58578644,7.41421356 C6.94771525,7.77614237 7.44771525,8 8,8 C8.55228475,8 9.05228475,7.77614237 9.41421356,7.41421356 C9.77614237,7.05228475 10,6.55228475 10,6 L10,4 L14,4 L14,6 C14,6.49091978 14.1768752,6.94052815 14.4703749,7.28857455 L14.5857864,7.41421356 C14.9477153,7.77614237 15.4477153,8 16,8 C16.5522847,8 17.0522847,7.77614237 17.4142136,7.41421356 C17.7761424,7.05228475 18,6.55228475 18,6 L18,4 L19,4 Z M8,2 C8.55228475,2 9,2.44771525 9,3 L9,6 C9,6.55228475 8.55228475,7 8,7 C7.44771525,7 7,6.55228475 7,6 L7,3 C7,2.44771525 7.44771525,2 8,2 Z M16,2 C16.5522847,2 17,2.44771525 17,3 L17,6 C17,6.55228475 16.5522847,7 16,7 C15.4477153,7 15,6.55228475 15,6 L15,3 C15,2.44771525 15.4477153,2 16,2 Z\"\/><\/g><\/svg><\/div><h5 class=\"pix-feature-title  font-weight-bold   text-white \" style=\"padding-top:20px;\"  >Make an appointment<\/h5><div class=\"pix-feature-content text-body-default      \" style=\"\"  ><\/div><\/div><\/a>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"pix-base-transition elementor-element elementor-element-1d0404bd e-con-full bg-dark-blur e-flex e-con e-child\" data-id=\"1d0404bd\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;pix_scale_in&quot;:&quot;none&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-192277b elementor-widget elementor-widget-pix-feature\" data-id=\"192277b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"pix-feature.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<a href=\"\/le-service\/\" ><div id=\"pix-feature-192277b\" class=\"pix-feature-el  text-custom \"><div class=\"pix-feature-icon d-inline-block mw-100 text-white \"   style=\"aspect-ratio:1\/1 !important;position:relative;text-align:center;font-size:1px;line-height:1px;\"><svg class=\"pixfort-icon \" width=\"24\" height=\"24\"  data-name=\"Duotone\/pixfort-icon-users-2\" viewBox=\"2 2 20 20\"><g fill=\"none\" fill-rule=\"evenodd\"><path fill=\"var(--pf-icon-color)\" fill-opacity=\".25\" d=\"M8.5,3 C10.9852814,3 13,5.01471863 13,7.5 C13,9.98528137 10.9852814,12 8.5,12 C6.01471863,12 4,9.98528137 4,7.5 C4,5.01471863 6.01471863,3 8.5,3 Z M15.5,3 C17.9852814,3 20,5.01471863 20,7.5 C20,9.98528137 17.9852814,12 15.5,12 C14.4476244,12 13.4796227,11.6387526 12.7132352,11.0334979 C13.5168958,10.078042 14,8.84543853 14,7.5 C14,6.15456147 13.5168958,4.92195798 12.7146919,3.96619398 C13.4796227,3.36124744 14.4476244,3 15.5,3 Z\"\/><path fill=\"var(--pf-icon-color)\" d=\"M8.4,13 C5.798822,13 3.75396103,14.1726441 2.37901154,16.444405 C2.09548025,16.9101552 1.94454731,17.4473717 1.94370085,17.9953861 C1.9411563,19.6522375 3.28223338,20.9974471 4.9390849,21 L11.859375,21 C12.4084564,20.9991532 12.9453208,20.8484782 13.4133368,20.5642998 C14.8296962,19.7042892 15.2805792,17.8588724 14.4200494,16.4428566 C13.046039,14.1726441 11.001178,13 8.4,13 Z M15.4,13 C18.001178,13 20.046039,14.1726441 21.4200494,16.4428566 C22.2805792,17.8588724 21.8296962,19.7042892 20.4133368,20.5642998 C19.9453208,20.8484782 19.4084564,20.9991532 18.859375,21 L14.8368013,21.0013558 C16.2550737,19.8357918 16.6377146,17.7748139 15.656601,16.1603756 C14.946022,14.9863196 14.0919073,14.0471004 13.1043953,13.3493638 C13.8104463,13.117273 14.5774052,13 15.4,13 Z\"\/><\/g><\/svg><\/div><h6 class=\"pix-feature-title  font-weight-bold   text-white \" style=\"padding-top:20px;\"  >Service<\/h6><div class=\"pix-feature-content text-body-default      \" style=\"\"  ><\/div><\/div><\/a>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>What are chordomas?Origin of chordomas?Who&#8217;s affected?Where are chordomas located? Chordomas are rare tumors that develop in the bones of the skull base or the spine. These are complex lesions requiring specialized management by an experienced multidisciplinary team. Our team has&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":8933,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-8900","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/pages\/8900","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/comments?post=8900"}],"version-history":[{"count":6,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/pages\/8900\/revisions"}],"predecessor-version":[{"id":661987,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/pages\/8900\/revisions\/661987"}],"up":[{"embeddable":true,"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/pages\/8933"}],"wp:attachment":[{"href":"https:\/\/www.neurochirurgie-lariboisiere.com\/en\/wp-json\/wp\/v2\/media?parent=8900"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}