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Combined petrosal approach for resection of a large left petroclival meningioma. Francesco Paglia, Lorenzo Giammattei, Paolo di Russo and Sebastien Froelich

Combined petrosal approach for resection of a large left petroclival meningioma. Francesco Paglia, Lorenzo Giammattei, Paolo di Russo and Sebastien Froelich

  Petroclival meningiomas represent the most complex lesions in skull base surgery, being closely related to critical neurovascular structures. The combined petrosal approach allows a wide exposure of the petroclival region and provides multiple angles of attack, limiting brain retraction. The authors present the case of a 54-year-old man with a large left petroclival meningioma […]

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In vivo efficacy assessment of the CDK4/6 inhibitor palbociclib and the PLK1 inhibitor volasertib in human chordoma xenografts

In vivo efficacy assessment of the CDK4/6 inhibitor palbociclib and the PLK1 inhibitor volasertib in human chordoma xenografts

  Abstract Background: Management of advanced chordomas remains delicate considering their insensitivity to chemotherapy. Homozygous deletion of the regulatory gene CDKN2A has been described as the most frequent genetic alteration in chordomas and may be considered as a potential theranostic marker. Here, we evaluated the tumor efficacy of the CDK4/6 inhibitor palbociclib, as well as […]

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Neurochirurgie guidée par l’image – Presentation du Pr Emmanuel Mandonnet au collège de France

Neurochirurgie guidée par l’image – Presentation du Pr Emmanuel Mandonnet au collège de France

  Neurochirurgie guidée par l’image – Presentation du Pr Emmanuel Mandonnet au Collège de France – 27 mai 2014       Au cours de cet exposé, nous analyserons comment différents modèles biomathématiques de l’évolution des gliomes intracérébraux et de leur interaction avec le fonctionnement cérébral peuvent – ou pourront dans un futur proche – aider le […]